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Production Rune used for Alchemy Recipes of level 11 and higher.
Every mob in the game has a chance to drop Production Runes.
Note: If your lvl is too high dropping Blend Rune from low level monsters is going to be difficult. At lvl 50, to drop 1 Blend Rune from a Wild Spider will take min. 30 mins. My suggestion is to create a new toon.
Bags containing 100 of any specific Production Rune can be bought in the Item Shop for 15 ($0.45)† (Ruby Bonus is 8 ).